https://doi.org/10.4081/peasa.16

Perspectives to fight viruses. The example of Sars-CoV-2

Vol. 1 (2022)
Published: October 7, 2022
Coronavirus, SARS-CoV-2, nanotechnology, nano thermodynamics, nano-platform, biophysics, complexity
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Authors

  • Costas Demetzos • demetzos@pharm.uoa.gr School of Health Sciences, Department of Pharmacy, Laboratory of Pharmaceutical Technology, Section of Pharmaceutical Nanotechnology, Panepistimiopolis Zografou, National and Kapodistrian University of Athens, Greece.
  • Panagiotis Vlamos Department of Informatics, Ionian University, Corfu, Greece.
  • Dimitrios Vlachakis Laboratory of Genetics, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, Greece.

Coronaviruses well studied in the past provide scientific tools and knowledge that is used for identifying the molecular basis of the new SARS-CoV-2. It belongs to complex systems and its evolution and mutations must be observed under the lens of the nonlinearity as it is far from the equilibrium conditions. The new properties that SARS-CoV-2 carries were incubated for a long time in microcosm refining its information content. Various animal species acted as transmitters of SARS-CoV-2 to human beings. In this perspective article, we argue that the infection ability of the new virus can correlate with its thermodynamic payload. Design: We suggest that by identifying the thermodynamic content and biophysical profile of the viruses’ proteins using a mathematical framework of nonlinear complex systems, we can simulate its molecular origin and design weapons for fighting it. We suggest discovering for artificial ‘decision-making’ nano-platforms that can decrypt the ‘crypted information code’ of viruses that permit their mutation process taking place not randomly but based on the self-assembly process of its nucleotides following the micro and macro environmental conditions. Main outcomes: Our proposition is to design nanoplatforms (decision making nanocarriers) that can carry thermodynamic variables that could interrupt the mutations, virulence, and proliferation. This approach is innovative and is a challenge that should be checked in the future. This concept needs generous funding by governments for supporting intelligence and innovative research projects. Mainly, we need solidarity between nations to shield the health of societies.

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Dimitrios Vlachakis, Laboratory of Genetics, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens

University Research Institute of Maternal and Child Health & Precision Medicine, Medical School, National and Kapodistrian University of Athens, Greece.

Division of Endocrinology and Metabolism, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Greece.

School of Informatics, Faculty of Natural and Mathematical Sciences, King's College London, Strand, London, UK.

How to Cite

Demetzos, C., Vlamos, P., & Vlachakis, D. (2022). Perspectives to fight viruses. The example of Sars-CoV-2. Proceedings of the European Academy of Sciences and Arts, 1(1). https://doi.org/10.4081/peasa.16
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